Antiproliferative action occurs with all DHEA metabolites.

2003 MAR 24 - (NewsRx.com & NewsRx.net) -- Antiproliferative action occurs with all DHEA metabolites.

"Dehydroepiandrosterone (DHEA) is a naturally occurring steroid synthesized in the adrenal cortex, gonads, brain, and gastrointestinal tract, and it is known to have chemopreventive and antiproliferative actions on tumors. These effects are considered to be induced by the inhibition of glucose-6-phosphate dehydrogenase (G6PD) and/or HMG-CoA reductase (HMGR) activities," researchers in Japan report.

"The present study was undertaken to investigate whether endogenous DHEA metabolites, i.e. DHEA-sulfate, 7-oxygenated DHEA derivatives, androsterone, …